Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (432 aa)    
Predicted Functional Partners:
NES
Nestin; Belongs to the intermediate filament family.
    
 
0.922
AQP4
Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family.
   
  
 0.882
CD68
CD68 molecule.
   
 
 0.879
MAPT
Microtubule-associated protein.
   
 
 0.879
CASP3
Caspase 3; Belongs to the peptidase C14A family.
   
 0.853
PXDN
Peroxidasin.
      
 0.829
PAX6
Paired box 6.
   
 
 0.826
NEFL
Neurofilament light; Belongs to the intermediate filament family.
   
 0.821
INA
Internexin neuronal intermediate filament protein alpha; Belongs to the intermediate filament family.
   
  0.819
BDNF
Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.
      
 0.818
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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