STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (432 aa)    
Predicted Functional Partners:
CD68
CD68 molecule.
   
 
 0.768
CASP3
Caspase 3; Belongs to the peptidase C14A family.
   
 0.732
PXDN
Peroxidasin.
   
  
 0.727
AQP4
Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family.
   
  
 0.706
DCX
Doublecortin.
    
 
 0.705
NES
Nestin; Belongs to the intermediate filament family.
    
 
0.686
PDGFRA
Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.
   
  
 0.658
IL6
Interleukin 6.
   
  
 0.657
S100B
Protein S100; Belongs to the S-100 family.
   
 
 0.626
G3T0K9_LOXAF
Uncharacterized protein.
   
  
 0.624
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.