| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADRB3 | CIDEA | ENSLAFP00000026999 | ENSLAFP00000002296 | G_PROTEIN_RECEP_F1_2 domain-containing protein. | Cell death inducing DFFA like effector a. | 0.436 |
| ADRB3 | UCP1 | ENSLAFP00000026999 | ENSLAFP00000005947 | G_PROTEIN_RECEP_F1_2 domain-containing protein. | Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.588 |
| CIDEA | ADRB3 | ENSLAFP00000002296 | ENSLAFP00000026999 | Cell death inducing DFFA like effector a. | G_PROTEIN_RECEP_F1_2 domain-containing protein. | 0.436 |
| CIDEA | LEP | ENSLAFP00000002296 | ENSLAFP00000008966 | Cell death inducing DFFA like effector a. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.453 |
| CIDEA | PLIN1 | ENSLAFP00000002296 | ENSLAFP00000005108 | Cell death inducing DFFA like effector a. | Perilipin; Belongs to the perilipin family. | 0.768 |
| CIDEA | PPARG | ENSLAFP00000002296 | ENSLAFP00000024076 | Cell death inducing DFFA like effector a. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.453 |
| CIDEA | UCP1 | ENSLAFP00000002296 | ENSLAFP00000005947 | Cell death inducing DFFA like effector a. | Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.447 |
| ELMOD2 | UCP1 | ENSLAFP00000023478 | ENSLAFP00000005947 | ELMO domain containing 2. | Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.422 |
| FGF21 | PPARG | ENSLAFP00000016854 | ENSLAFP00000024076 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.487 |
| FGF21 | UCP1 | ENSLAFP00000016854 | ENSLAFP00000005947 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.725 |
| LEP | CIDEA | ENSLAFP00000008966 | ENSLAFP00000002296 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Cell death inducing DFFA like effector a. | 0.453 |
| LEP | PLIN1 | ENSLAFP00000008966 | ENSLAFP00000005108 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Perilipin; Belongs to the perilipin family. | 0.571 |
| LEP | PPARG | ENSLAFP00000008966 | ENSLAFP00000024076 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.689 |
| LEP | TH | ENSLAFP00000008966 | ENSLAFP00000021655 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Tyrosine hydroxylase. | 0.635 |
| LEP | UCP1 | ENSLAFP00000008966 | ENSLAFP00000005947 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.429 |
| PLIN1 | CIDEA | ENSLAFP00000005108 | ENSLAFP00000002296 | Perilipin; Belongs to the perilipin family. | Cell death inducing DFFA like effector a. | 0.768 |
| PLIN1 | LEP | ENSLAFP00000005108 | ENSLAFP00000008966 | Perilipin; Belongs to the perilipin family. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.571 |
| PLIN1 | PPARG | ENSLAFP00000005108 | ENSLAFP00000024076 | Perilipin; Belongs to the perilipin family. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.598 |
| PLIN1 | UCP1 | ENSLAFP00000005108 | ENSLAFP00000005947 | Perilipin; Belongs to the perilipin family. | Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.428 |
| PPARG | CIDEA | ENSLAFP00000024076 | ENSLAFP00000002296 | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | Cell death inducing DFFA like effector a. | 0.453 |
STRING v12.5 is now available!
