Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
CBLCbl proto-oncogene. (906 aa)    
Predicted Functional Partners:
GRB2
Growth factor receptor bound protein 2.
    
 0.997
EGFR
Receptor protein-tyrosine kinase.
    
 0.996
VAV1
Vav guanine nucleotide exchange factor 1.
    
 0.996
SPRY2
Sprouty RTK signaling antagonist 2.
    
 0.995
SH3KBP1
SH3 domain containing kinase binding protein 1.
    
 0.995
CRKL
CRK like proto-oncogene, adaptor protein.
    
 0.993
CRK
CRK proto-oncogene, adaptor protein.
    
 0.992
MET
Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]
    
 0.991
PIK3R1
Phosphoinositide-3-kinase regulatory subunit 1.
    
 0.991
PIK3R2
Uncharacterized protein.
    
 0.990
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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