RAD1 protein (Loxodonta africana) - STRING interaction network

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RAD1

RAD1 checkpoint DNA exonuclease. (280 aa)

Predicted Functional Partners:

RAD9A

0.998

HUS1

0.994

RAD9B

0.989

RAD17

0.987

ATR

0.975

RFC4

0.955

WRN

0.934

ZBTB14

0.927

ATM

0.920

RPA1

0.910

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	ATR	ENSLAFP00000006871	ENSLAFP00000012949	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.987
ATM	HUS1	ENSLAFP00000006871	ENSLAFP00000014960	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Checkpoint protein; Belongs to the HUS1 family.	0.834
ATM	RAD1	ENSLAFP00000006871	ENSLAFP00000006094	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	RAD1 checkpoint DNA exonuclease.	0.920
ATM	RAD17	ENSLAFP00000006871	ENSLAFP00000010102	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	RAD17 checkpoint clamp loader component.	0.945
ATM	RAD9A	ENSLAFP00000006871	ENSLAFP00000007488	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.921
ATM	RAD9B	ENSLAFP00000006871	ENSLAFP00000005188	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.888
ATM	RFC4	ENSLAFP00000006871	ENSLAFP00000020486	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Replication factor C subunit 4.	0.846
ATM	RPA1	ENSLAFP00000006871	ENSLAFP00000012864	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.928
ATM	WRN	ENSLAFP00000006871	ENSLAFP00000003703	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	WRN RecQ like helicase.	0.982
ATR	ATM	ENSLAFP00000012949	ENSLAFP00000006871	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.987
ATR	HUS1	ENSLAFP00000012949	ENSLAFP00000014960	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Checkpoint protein; Belongs to the HUS1 family.	0.978
ATR	RAD1	ENSLAFP00000012949	ENSLAFP00000006094	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	RAD1 checkpoint DNA exonuclease.	0.975
ATR	RAD17	ENSLAFP00000012949	ENSLAFP00000010102	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	RAD17 checkpoint clamp loader component.	0.972
ATR	RAD9A	ENSLAFP00000012949	ENSLAFP00000007488	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.983
ATR	RAD9B	ENSLAFP00000012949	ENSLAFP00000005188	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.956
ATR	RFC4	ENSLAFP00000012949	ENSLAFP00000020486	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Replication factor C subunit 4.	0.803
ATR	RPA1	ENSLAFP00000012949	ENSLAFP00000012864	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.933
ATR	WRN	ENSLAFP00000012949	ENSLAFP00000003703	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	WRN RecQ like helicase.	0.975
HUS1	ATM	ENSLAFP00000014960	ENSLAFP00000006871	Checkpoint protein; Belongs to the HUS1 family.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.834
HUS1	ATR	ENSLAFP00000014960	ENSLAFP00000012949	Checkpoint protein; Belongs to the HUS1 family.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.978

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