Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CDK18Cyclin dependent kinase 18; Belongs to the protein kinase superfamily. (449 aa)    
Predicted Functional Partners:
CDK15
Cyclin dependent kinase 15; Belongs to the protein kinase superfamily.
    
   0.788
YWHAQ
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family.
    
 0.681
YWHAB
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family.
    
 0.663
SUMF2
FGE-sulfatase domain-containing protein.
    
 0.654
CDC6
Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.
   
 0.652
MCM3
DNA helicase; Belongs to the MCM family.
   
 0.646
CCNA1
Cyclin A1; Belongs to the cyclin family.
   
 0.641
CCNA2
Cyclin A2; Belongs to the cyclin family.
   
 0.641
MCM4
DNA helicase; Belongs to the MCM family.
   
 0.641
CDKN1B
Cyclin dependent kinase inhibitor 1B.
   
 0.639
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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