STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CTSBCathepsin B; Belongs to the peptidase C1 family. (342 aa)    
Predicted Functional Partners:
NLRP3
NLR family pyrin domain containing 3.
    
 0.957
BCL2
BCL2 apoptosis regulator.
   
 
 0.918
BCL2L1
BCL2 like 1.
   
 
 0.908
BID
BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.
   
 
 0.906
LGMN
Legumain.
   
 
 0.741
ASGR1
Asialoglycoprotein receptor 1.
   
 0.736
KREMEN1
Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.
      
 0.723
PHEX
Phosphate regulating endopeptidase homolog X-linked.
      
 0.719
CTSD
Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.
   
 0.718
BIRC5
Baculoviral IAP repeat containing 5.
     
 0.693
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.