Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
SLX4SLX4 structure-specific endonuclease subunit. (1601 aa)    
Predicted Functional Partners:
EPRS1
Glutamyl-prolyl-tRNA synthetase.
  
 0.997
GIYD1
Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.
   
 0.997
MUS81
MUS81 structure-specific endonuclease subunit.
   
 0.993
EME1
Essential meiotic structure-specific endonuclease 1.
    
 0.992
ERCC1
ERCC excision repair 1, endonuclease non-catalytic subunit.
   
 0.990
ERCC4
ERCC excision repair 4, endonuclease catalytic subunit.
   
 0.989
YARS1
Tyrosine--tRNA ligase.
  
 0.945
FANCD2
FA complementation group D2.
    
 0.907
TERF2IP
TERF2 interacting protein.
    
 
 0.907
FANCM
FA complementation group M.
   
 0.892
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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