SPAST protein (Loxodonta africana) - STRING interaction network

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SPAST

Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] (616 aa)

Predicted Functional Partners:

UBXN7

0.946

UFD1

0.671

IST1

0.639

G3U0Z3_LOXAF

0.639

YOD1

0.605

BSCL2

0.601

UBXN1

0.597

REEP1

0.592

NPLOC4

0.588

FAAP100

0.586

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BSCL2	REEP1	ENSLAFP00000022464	ENSLAFP00000001113	BSCL2 lipid droplet biogenesis associated, seipin.	Receptor expression-enhancing protein.	0.611
BSCL2	SPAST	ENSLAFP00000022464	ENSLAFP00000006226	BSCL2 lipid droplet biogenesis associated, seipin.	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...]	0.601
FAAP100	SPAST	ENSLAFP00000028991	ENSLAFP00000006226	FA core complex associated protein 100.	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...]	0.586
FAAP100	UBXN7	ENSLAFP00000028991	ENSLAFP00000026718	FA core complex associated protein 100.	UBX domain-containing protein 7.	0.999
FAAP100	UFD1	ENSLAFP00000028991	ENSLAFP00000009261	FA core complex associated protein 100.	Ubiquitin recognition factor in ER associated degradation 1.	0.962
FAAP100	YOD1	ENSLAFP00000028991	ENSLAFP00000016523	FA core complex associated protein 100.	YOD1 deubiquitinase.	0.872
G3U0Z3_LOXAF	SPAST	ENSLAFP00000021501	ENSLAFP00000006226	Uncharacterized protein.	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...]	0.639
IST1	SPAST	ENSLAFP00000013703	ENSLAFP00000006226	IST1 factor associated with ESCRT-III.	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...]	0.639
NPLOC4	SPAST	ENSLAFP00000025950	ENSLAFP00000006226	NPL4 homolog, ubiquitin recognition factor.	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...]	0.588
NPLOC4	UBXN1	ENSLAFP00000025950	ENSLAFP00000017372	NPL4 homolog, ubiquitin recognition factor.	UBX domain protein 1.	0.604
NPLOC4	UBXN7	ENSLAFP00000025950	ENSLAFP00000026718	NPL4 homolog, ubiquitin recognition factor.	UBX domain-containing protein 7.	0.999
NPLOC4	UFD1	ENSLAFP00000025950	ENSLAFP00000009261	NPL4 homolog, ubiquitin recognition factor.	Ubiquitin recognition factor in ER associated degradation 1.	0.999
NPLOC4	YOD1	ENSLAFP00000025950	ENSLAFP00000016523	NPL4 homolog, ubiquitin recognition factor.	YOD1 deubiquitinase.	0.872
REEP1	BSCL2	ENSLAFP00000001113	ENSLAFP00000022464	Receptor expression-enhancing protein.	BSCL2 lipid droplet biogenesis associated, seipin.	0.611
REEP1	SPAST	ENSLAFP00000001113	ENSLAFP00000006226	Receptor expression-enhancing protein.	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...]	0.592
SPAST	BSCL2	ENSLAFP00000006226	ENSLAFP00000022464	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...]	BSCL2 lipid droplet biogenesis associated, seipin.	0.601
SPAST	FAAP100	ENSLAFP00000006226	ENSLAFP00000028991	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...]	FA core complex associated protein 100.	0.586
SPAST	G3U0Z3_LOXAF	ENSLAFP00000006226	ENSLAFP00000021501	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...]	Uncharacterized protein.	0.639
SPAST	IST1	ENSLAFP00000006226	ENSLAFP00000013703	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...]	IST1 factor associated with ESCRT-III.	0.639
SPAST	NPLOC4	ENSLAFP00000006226	ENSLAFP00000025950	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...]	NPL4 homolog, ubiquitin recognition factor.	0.588

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