Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
KRT73Keratin 73; Belongs to the intermediate filament family. (523 aa)    
Predicted Functional Partners:
DSG4
Desmoglein 4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
  
 0.858
DSG2
Desmoglein 2.
   
 
 0.807
DSG1
Desmoglein 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
   
 
 0.805
KRT27
Keratin 27; Belongs to the intermediate filament family.
  
0.584
KRT74
Keratin 74; Belongs to the intermediate filament family.
   
 
  0.475
ZDHHC13
Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.
      
 0.462
KRT35
Keratin 35; Belongs to the intermediate filament family.
   
 0.448
KRTAP7-1
Keratin associated protein 7-1 (gene/pseudogene).
   
  
 0.429
KRT77
Keratin 77; Belongs to the intermediate filament family.
   
  0.426
FECH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.
      
 0.416
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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