STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
JAK2Tyrosine-protein kinase. (1132 aa)    
Predicted Functional Partners:
SOCS3
Suppressor of cytokine signaling 3.
   
 0.997
STAT3
Signal transducer and activator of transcription.
   
 0.996
LEPR
Leptin receptor.
    
 0.994
STAT1
Signal transducer and activator of transcription.
   
 0.993
GHR
Growth hormone receptor.
    
 0.993
IFNGR2
Interferon gamma receptor 2.
   
 0.991
JAK1
Tyrosine-protein kinase.
   
0.990
PRLR
Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin.
    
 0.988
EPOR
Erythropoietin receptor.
    
 0.988
IL12RB1
Interleukin 12 receptor subunit beta 1.
   
 0.987
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.