Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ABRAXAS2Abraxas 2, BRISC complex subunit. (415 aa)    
Predicted Functional Partners:
BABAM2
BRISC and BRCA1 A complex member 2.
    
 0.997
BRCC3
BRCA1/BRCA2-containing complex subunit 3.
    
 0.997
BABAM1
Uncharacterized protein.
    
 0.997
SHMT2
Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.
    
 0.826
BRCA1
Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]
    
 0.770
SHMT1
Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.
    
 
 0.739
USP7
Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family.
    
 0.708
WWP2
E3 ubiquitin-protein ligase.
    
 0.616
SWAP70
Switching B cell complex subunit SWAP70.
    
   0.606
C9orf85
Chromosome 9 open reading frame 85.
    
   0.594
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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