Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PLEKHA1Pleckstrin homology domain containing A1. (385 aa)    
Predicted Functional Partners:
PTPN13
Tyrosine-protein phosphatase non-receptor type 13; Regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling.
    
  0.722
MYSM1
Myb like, SWIRM and MPN domains 1.
    
 0.673
UBA52
Ubiquitin A-52 residue ribosomal protein fusion product 1.
    
 0.449
H2AZ2
Histone H2A; Belongs to the histone H2A family.
   
 0.426
H2AZ1
Histone H2A; Belongs to the histone H2A family.
   
 0.426
KDM6A
Lysine demethylase 6A.
    
 0.420
GLYR1
Glyoxylate reductase 1 homolog.
    
   0.402
LOC111752376
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
   
 0.401
PAXIP1
PAX interacting protein 1.
    
 0.401
MDC1
Mediator of DNA damage checkpoint 1.
    
 0.401
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.