STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CA4Carbonic anhydrase 4; Belongs to the alpha-carbonic anhydrase family. (311 aa)    
Predicted Functional Partners:
RPF2
Ribosome production factor 2 homolog.
   
 
 0.529
HIF1A
Hypoxia inducible factor 1 subunit alpha.
   
 0.511
LEP
Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]
   
  
 0.490
FXR2
FMR1 autosomal homolog 2.
      
 0.486
CA14
Carbonic anhydrase 14; Belongs to the alpha-carbonic anhydrase family.
  
  
0.474
NOC2L
Uncharacterized protein.
   
  
 0.466
CA12
Carbonic anhydrase 12; Belongs to the alpha-carbonic anhydrase family.
  
  
0.465
CA1
Carbonic anhydrase 1; Belongs to the alpha-carbonic anhydrase family.
  
 
0.464
GRWD1
Glutamate rich WD repeat containing 1.
   
  
 0.454
WDR43
WD repeat domain 43.
   
    0.441
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.