Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
EPHA2EPH receptor A2. (977 aa)    
Predicted Functional Partners:
EFNA1
Ephrin A1; Belongs to the ephrin family.
   
 0.998
EFNA5
Ephrin A5; Belongs to the ephrin family.
   
 0.991
EFNA3
Ephrin RBD domain-containing protein; Belongs to the ephrin family.
   
 0.990
EFNA4
Ephrin A4; Belongs to the ephrin family.
   
 0.962
CBL
Cbl proto-oncogene.
    
 0.939
GRB2
Growth factor receptor bound protein 2.
   
 0.907
EGF
Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.
    
 0.894
CRK
CRK proto-oncogene, adaptor protein.
   
 0.893
FLT3LG
Fms related tyrosine kinase 3 ligand.
    
 0.892
INS
Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
    
 0.891
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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