Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
IL33Uncharacterized protein. (59 aa)    
Predicted Functional Partners:
IL1RL1
Interleukin 1 receptor like 1.
    
 0.992
IL1RAP
Interleukin 1 receptor accessory protein.
    
 0.982
G3TMS6_LOXAF
Uncharacterized protein; Belongs to the peptidase C14A family.
    
 0.887
CASP12
Caspase 12 (gene/pseudogene); Belongs to the peptidase C14A family.
    
 0.887
TSLP
Uncharacterized protein.
      
 0.819
G3TH08_LOXAF
CARD domain-containing protein.
    
 0.816
IL13
Interleukin 13.
      
 0.814
IFNG
Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
      
 0.808
IL5
Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells.
      
 0.801
IL18R1
Interleukin 18 receptor 1.
     
 0.800
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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