Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
GOPCPDZ domain-containing protein. (468 aa)    
Predicted Functional Partners:
CFTR
Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]
    
 0.973
RHOQ
Ras homolog family member Q.
    
 0.877
SUOX
Sulfite oxidase.
     
  0.790
RHOJ
Ras homolog family member J.
    
 0.689
TTC26
Tetratricopeptide repeat domain 26.
    
 0.646
ROS1
Tyrosine-protein kinase receptor.
    
 0.643
RHOH
Ras homolog family member H.
    
 0.627
PICK1
Protein interacting with PRKCA 1.
   
 0.627
WIPI2
WD repeat domain, phosphoinositide interacting 2.
      
 0.624
TOX4
TOX high mobility group box family member 4.
   
 
 0.554
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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