STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
IL18R1Interleukin 18 receptor 1. (539 aa)    
Predicted Functional Partners:
IL18RAP
Interleukin 18 receptor accessory protein.
   
0.996
IL18
Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.
   
 0.958
IL33
Uncharacterized protein.
     
 0.800
ZPBP
Zona pellucida binding protein.
      
 0.708
IL18BP
Interleukin 18 binding protein.
     
 0.706
HESX1
HESX homeobox 1.
      
 0.660
RABEP2
Rabaptin, RAB GTPase binding effector protein 2.
      
 0.641
MFSD9
Major facilitator superfamily domain containing 9.
      
 0.621
IL1A
Interleukin-1; Belongs to the IL-1 family.
     
 0.620
SGF29
SAGA complex associated factor 29.
      
 0.616
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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