STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IL18R1Interleukin 18 receptor 1. (539 aa)    
Predicted Functional Partners:
IL18RAP
Interleukin 18 receptor accessory protein.
   
0.995
IL18
Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.
   
 0.991
IL1RAP
Interleukin 1 receptor accessory protein.
    
 
0.604
MFSD9
Major facilitator superfamily domain containing 9.
      
 0.579
IL33
Uncharacterized protein.
      
 0.525
HESX1
HESX homeobox 1.
      
 0.515
RABEP2
Rabaptin, RAB GTPase binding effector protein 2.
      
 0.513
IL18BP
Interleukin 18 binding protein.
     
 0.510
IL1F10
Interleukin-1.
   
 0.487
IL12RB1
Interleukin 12 receptor subunit beta 1.
    
 
 0.478
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.