Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (974 aa)    
Predicted Functional Partners:
CASP3
Caspase 3; Belongs to the peptidase C14A family.
    
 0.997
CASP7
Caspase 7; Belongs to the peptidase C14A family.
    
 0.987
PARG
Poly(ADP-ribose) glycohydrolase.
    
 0.985
CHD1L
Chromodomain helicase DNA binding protein 1 like.
   
 0.978
PARP3
Poly [ADP-ribose] polymerase.
    
 0.975
XRCC1
X-ray repair cross complementing 1.
    
 
 0.968
XPC
XPC complex subunit, DNA damage recognition and repair factor.
   
 0.966
CASP9
Caspase 9; Belongs to the peptidase C14A family.
    
 0.964
MACROH2A1
Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.
   
 
 0.962
PARP2
Poly [ADP-ribose] polymerase.
   
 0.962
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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