Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CLSPNClaspin. (1304 aa)    
Predicted Functional Partners:
CHEK1
Checkpoint kinase 1; Belongs to the protein kinase superfamily.
   
 0.997
RPA1
Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
    
 0.969
CDC45
Cell division cycle 45.
   
 0.963
BTRC
Beta-transducin repeat containing E3 ubiquitin protein ligase.
    
 
 0.953
TIMELESS
Timeless circadian regulator.
   
 0.950
PRIMPOL
Primase and DNA directed polymerase.
   
 
 0.949
CDC7
Cell division cycle 7.
   
 0.945
RAD9A
Cell cycle checkpoint control protein; Belongs to the rad9 family.
   
 0.935
WRN
WRN RecQ like helicase.
   
 0.926
ATR
ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.
    
 0.922
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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