Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
OLIG1Oligodendrocyte transcription factor 1. (156 aa)    
Predicted Functional Partners:
SOX8
SRY-box transcription factor 8.
   
 
 0.627
NKX2-2
NK2 homeobox 2.
   
 0.580
NES
Nestin; Belongs to the intermediate filament family.
      
 0.558
BDNF
Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.
      
 0.556
CNP
2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin; Belongs to the 2H phosphoesterase superfamily. CNPase family.
      
 0.554
ATOH1
Atonal bHLH transcription factor 1.
    
 
 0.541
NRG1
Neuregulin 1.
      
 0.528
GFAP
Glial fibrillary acidic protein; Belongs to the intermediate filament family.
   
 
 0.519
DLX1
Distal-less homeobox 1.
   
  
 0.517
BCAS1
Breast carcinoma amplified sequence 1.
   
  
 0.516
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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