KDM1A protein (Loxodonta africana) - STRING interaction network

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KDM1A

Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (875 aa)

Predicted Functional Partners:

RCOR1

0.999

PHF21A

0.997

HMG20B

0.995

ZMYM2

0.994

ZMYM3

0.987

ZNF217

0.981

HMG20A

0.975

SNAI1

0.952

TRIM28

0.950

REST

0.943

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HMG20A	HMG20B	ENSLAFP00000015308	ENSLAFP00000018289	High mobility group 20A.	High mobility group 20B.	0.955
HMG20A	KDM1A	ENSLAFP00000015308	ENSLAFP00000006696	High mobility group 20A.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.975
HMG20A	PHF21A	ENSLAFP00000015308	ENSLAFP00000002984	High mobility group 20A.	PHD finger protein 21A.	0.974
HMG20A	RCOR1	ENSLAFP00000015308	ENSLAFP00000004634	High mobility group 20A.	REST corepressor 1.	0.964
HMG20A	SNAI1	ENSLAFP00000015308	ENSLAFP00000028752	High mobility group 20A.	Snail family transcriptional repressor 1.	0.927
HMG20B	HMG20A	ENSLAFP00000018289	ENSLAFP00000015308	High mobility group 20B.	High mobility group 20A.	0.955
HMG20B	KDM1A	ENSLAFP00000018289	ENSLAFP00000006696	High mobility group 20B.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.995
HMG20B	PHF21A	ENSLAFP00000018289	ENSLAFP00000002984	High mobility group 20B.	PHD finger protein 21A.	0.996
HMG20B	RCOR1	ENSLAFP00000018289	ENSLAFP00000004634	High mobility group 20B.	REST corepressor 1.	0.995
HMG20B	REST	ENSLAFP00000018289	ENSLAFP00000024429	High mobility group 20B.	RE1 silencing transcription factor.	0.625
HMG20B	SNAI1	ENSLAFP00000018289	ENSLAFP00000028752	High mobility group 20B.	Snail family transcriptional repressor 1.	0.927
HMG20B	ZMYM2	ENSLAFP00000018289	ENSLAFP00000018606	High mobility group 20B.	Zinc finger MYM-type containing 2.	0.416
KDM1A	HMG20A	ENSLAFP00000006696	ENSLAFP00000015308	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	High mobility group 20A.	0.975
KDM1A	HMG20B	ENSLAFP00000006696	ENSLAFP00000018289	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	High mobility group 20B.	0.995
KDM1A	PHF21A	ENSLAFP00000006696	ENSLAFP00000002984	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	PHD finger protein 21A.	0.997
KDM1A	RCOR1	ENSLAFP00000006696	ENSLAFP00000004634	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	REST corepressor 1.	0.999
KDM1A	REST	ENSLAFP00000006696	ENSLAFP00000024429	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	RE1 silencing transcription factor.	0.943
KDM1A	SNAI1	ENSLAFP00000006696	ENSLAFP00000028752	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	Snail family transcriptional repressor 1.	0.952
KDM1A	TRIM28	ENSLAFP00000006696	ENSLAFP00000022715	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	Tripartite motif containing 28.	0.950
KDM1A	ZMYM2	ENSLAFP00000006696	ENSLAFP00000018606	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	Zinc finger MYM-type containing 2.	0.994

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