| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MED1 | NCOA1 | ENSLAFP00000000953 | ENSLAFP00000012099 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor coactivator. | 0.823 |
| MED1 | NCOA2 | ENSLAFP00000000953 | ENSLAFP00000007644 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor coactivator. | 0.795 |
| MED1 | NCOA3 | ENSLAFP00000000953 | ENSLAFP00000000544 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor coactivator. | 0.914 |
| MED1 | NCOR1 | ENSLAFP00000000953 | ENSLAFP00000028513 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor corepressor 1. | 0.679 |
| MED1 | NR1I3 | ENSLAFP00000000953 | ENSLAFP00000000995 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor subfamily 1 group I member 3. | 0.920 |
| MED1 | PPARA | ENSLAFP00000000953 | ENSLAFP00000011195 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Peroxisome proliferator activated receptor alpha. | 0.936 |
| MED1 | PPARD | ENSLAFP00000000953 | ENSLAFP00000014816 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Peroxisome proliferator activated receptor delta. | 0.610 |
| MED1 | PPARG | ENSLAFP00000000953 | ENSLAFP00000024076 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.972 |
| MED1 | RXRG | ENSLAFP00000000953 | ENSLAFP00000006754 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Retinoid X receptor gamma. | 0.946 |
| MED1 | THRB | ENSLAFP00000000953 | ENSLAFP00000011656 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Thyroid hormone receptor beta. | 0.958 |
| NCOA1 | MED1 | ENSLAFP00000012099 | ENSLAFP00000000953 | Nuclear receptor coactivator. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.823 |
| NCOA1 | NCOA2 | ENSLAFP00000012099 | ENSLAFP00000007644 | Nuclear receptor coactivator. | Nuclear receptor coactivator. | 0.977 |
| NCOA1 | NCOA3 | ENSLAFP00000012099 | ENSLAFP00000000544 | Nuclear receptor coactivator. | Nuclear receptor coactivator. | 0.972 |
| NCOA1 | NCOR1 | ENSLAFP00000012099 | ENSLAFP00000028513 | Nuclear receptor coactivator. | Nuclear receptor corepressor 1. | 0.703 |
| NCOA1 | NR1I3 | ENSLAFP00000012099 | ENSLAFP00000000995 | Nuclear receptor coactivator. | Nuclear receptor subfamily 1 group I member 3. | 0.631 |
| NCOA1 | PPARA | ENSLAFP00000012099 | ENSLAFP00000011195 | Nuclear receptor coactivator. | Peroxisome proliferator activated receptor alpha. | 0.959 |
| NCOA1 | PPARD | ENSLAFP00000012099 | ENSLAFP00000014816 | Nuclear receptor coactivator. | Peroxisome proliferator activated receptor delta. | 0.849 |
| NCOA1 | PPARG | ENSLAFP00000012099 | ENSLAFP00000024076 | Nuclear receptor coactivator. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.965 |
| NCOA1 | RXRG | ENSLAFP00000012099 | ENSLAFP00000006754 | Nuclear receptor coactivator. | Retinoid X receptor gamma. | 0.946 |
| NCOA1 | THRB | ENSLAFP00000012099 | ENSLAFP00000011656 | Nuclear receptor coactivator. | Thyroid hormone receptor beta. | 0.992 |
