Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PAK5Non-specific serine/threonine protein kinase. (721 aa)    
Predicted Functional Partners:
CDC42
Uncharacterized protein.
   
 0.958
PAK6
Non-specific serine/threonine protein kinase.
   
 0.876
NCK2
Cytoplasmic protein.
    
 0.872
NCK1
Cytoplasmic protein.
    
 0.872
ARHGEF7
Rho guanine nucleotide exchange factor 7.
    
 0.847
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor 6.
    
 0.847
INKA1
Inka box actin regulator 1.
    
 
 0.840
LIMK1
LIM domain kinase 1.
    
 0.824
LIMK2
LIM domain kinase 2.
    
 0.820
MAP2K1
Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.
    
 0.819
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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