STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HECTD4HECT domain E3 ubiquitin protein ligase 4. (4127 aa)    
Predicted Functional Partners:
EVC
EvC ciliary complex subunit 1.
   
 0.726
GGA3
Golgi associated, gamma adaptin ear containing, ARF binding protein 3.
   
 
 0.686
SLC17A3
Solute carrier family 17 member 3.
    
 
 0.586
ACAD10
Acyl-CoA dehydrogenase family member 10.
    
 
 0.574
CDSN
Corneodesmosin.
      
 0.524
RANBP2
RAN binding protein 2.
   
 0.520
MT-ND4
NADH-ubiquinone oxidoreductase chain 4; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
    
 
 0.476
ADGRD1
Adhesion G protein-coupled receptor D1; Belongs to the G-protein coupled receptor 2 family.
    
 0.460
ADGRB3
Adhesion G protein-coupled receptor B3; Belongs to the G-protein coupled receptor 2 family.
    
 0.460
RAN
GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.
    
 0.460
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.