STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
NSD2Nuclear receptor binding SET domain protein 2. (1361 aa)    
Predicted Functional Partners:
G3UG48_LOXAF
Uncharacterized protein.
   
 0.937
CAMKMT
Calmodulin-lysine N-methyltransferase.
     
 0.885
PLOD2
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2.
    
 0.881
PLOD3
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3.
    
 0.881
PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1.
    
 0.881
RRP8
Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...]
   
 0.809
ASH1L
ASH1 like histone lysine methyltransferase.
   
 
 0.778
SMYD2
SET and MYND domain containing 2.
   
 
 0.747
SETD2
SET domain containing 2, histone lysine methyltransferase.
   
 
 0.731
BRD3
Bromodomain containing 3.
   
 0.714
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.