Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DDX51DEAD-box helicase 51; Belongs to the DEAD box helicase family. (587 aa)    
Predicted Functional Partners:
RRP8
Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...]
   
 
 0.813
NOL8
Nucleolar protein 8.
   
 
 0.808
EBNA1BP2
EBNA1 binding protein 2.
   
 0.768
RPL4
Ribosomal protein L4.
   
 0.754
RRP9
Ribosomal RNA processing 9, U3 small nucleolar RNA binding protein.
   
 0.726
DHX9
DExH-box helicase 9.
   
 0.721
NOP14
NOP14 nucleolar protein.
   
 0.720
ARRDC2
Arrestin domain containing 2.
    
 
 0.719
PES1
Pescadillo ribosomal biogenesis factor 1.
   
 0.717
WDR61
WD repeat domain 61.
   
 0.710
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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