Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
FAT2FAT atypical cadherin 2. (4340 aa)    
Predicted Functional Partners:
FJX1
Four-jointed box kinase 1.
   
 0.869
FRMD6
FERM domain containing 6.
    
 0.716
CAPZB
F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
      
 0.696
RERE
Arginine-glutamic acid dipeptide repeats.
    
 0.655
ATN1
Atrophin 1.
    
 0.655
ITGA10
Integrin subunit alpha 10; Belongs to the integrin alpha chain family.
   
  
 0.629
CSNK1D
Casein kinase 1 delta.
    
 0.621
LOC100666300
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
    
 0.621
EVL
Enah/Vasp-like; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family.
   
 
 0.602
FASTKD1
FAST kinase domains 1.
      
 0.561
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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