MAP11 protein (Loxodonta africana) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

MAP11

Microtubule associated protein 11. (580 aa)

Predicted Functional Partners:

TRAPPC1

0.656

TRAPPC5

0.607

CLPX

0.586

MAP10

0.526

CABS1

0.493

TRAPPC2B

0.480

BCL2L14

0.463

CREB3L2

0.445

NCAPH

0.422

TRAPPC12

0.405

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL2L14	MAP11	ENSLAFP00000027607	ENSLAFP00000007124	BCL2 like 14.	Microtubule associated protein 11.	0.463
BCL2L14	TRAPPC1	ENSLAFP00000027607	ENSLAFP00000000444	BCL2 like 14.	Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family.	0.497
BCL2L14	TRAPPC5	ENSLAFP00000027607	ENSLAFP00000004909	BCL2 like 14.	Trafficking protein particle complex subunit 5; May play a role in vesicular transport from endoplasmic reticulum to Golgi.	0.491
CABS1	MAP11	ENSLAFP00000025045	ENSLAFP00000007124	Calcium binding protein, spermatid associated 1.	Microtubule associated protein 11.	0.493
CABS1	TRAPPC1	ENSLAFP00000025045	ENSLAFP00000000444	Calcium binding protein, spermatid associated 1.	Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family.	0.497
CABS1	TRAPPC5	ENSLAFP00000025045	ENSLAFP00000004909	Calcium binding protein, spermatid associated 1.	Trafficking protein particle complex subunit 5; May play a role in vesicular transport from endoplasmic reticulum to Golgi.	0.491
CLPX	MAP11	ENSLAFP00000004163	ENSLAFP00000007124	Caseinolytic mitochondrial matrix peptidase chaperone subunit.	Microtubule associated protein 11.	0.586
CREB3L2	MAP11	ENSLAFP00000007110	ENSLAFP00000007124	cAMP responsive element binding protein 3 like 2.	Microtubule associated protein 11.	0.445
MAP10	MAP11	ENSLAFP00000028603	ENSLAFP00000007124	Microtubule associated protein 10.	Microtubule associated protein 11.	0.526
MAP11	BCL2L14	ENSLAFP00000007124	ENSLAFP00000027607	Microtubule associated protein 11.	BCL2 like 14.	0.463
MAP11	CABS1	ENSLAFP00000007124	ENSLAFP00000025045	Microtubule associated protein 11.	Calcium binding protein, spermatid associated 1.	0.493
MAP11	CLPX	ENSLAFP00000007124	ENSLAFP00000004163	Microtubule associated protein 11.	Caseinolytic mitochondrial matrix peptidase chaperone subunit.	0.586
MAP11	CREB3L2	ENSLAFP00000007124	ENSLAFP00000007110	Microtubule associated protein 11.	cAMP responsive element binding protein 3 like 2.	0.445
MAP11	MAP10	ENSLAFP00000007124	ENSLAFP00000028603	Microtubule associated protein 11.	Microtubule associated protein 10.	0.526
MAP11	NCAPH	ENSLAFP00000007124	ENSLAFP00000017865	Microtubule associated protein 11.	Non-SMC condensin I complex subunit H.	0.422
MAP11	TRAPPC1	ENSLAFP00000007124	ENSLAFP00000000444	Microtubule associated protein 11.	Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family.	0.656
MAP11	TRAPPC12	ENSLAFP00000007124	ENSLAFP00000004102	Microtubule associated protein 11.	Trafficking protein particle complex 12.	0.405
MAP11	TRAPPC2B	ENSLAFP00000007124	ENSLAFP00000012053	Microtubule associated protein 11.	Trafficking protein particle complex 2B.	0.480
MAP11	TRAPPC5	ENSLAFP00000007124	ENSLAFP00000004909	Microtubule associated protein 11.	Trafficking protein particle complex subunit 5; May play a role in vesicular transport from endoplasmic reticulum to Golgi.	0.607
NCAPH	MAP11	ENSLAFP00000017865	ENSLAFP00000007124	Non-SMC condensin I complex subunit H.	Microtubule associated protein 11.	0.422

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

38

average node degree:

6.91

avg. local clustering coefficient:

0.859

expected number of edges:

13

PPI enrichment p-value:

5.81e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007218

Neuropeptide signaling pathway

5 of 111

1.96

2.45

6.23e-06

GO:0007186

G protein-coupled receptor signaling pathway

11 of 1020

1.34

2.31

1.52e-11

GO:0007600

Sensory perception

4 of 347

1.37

0.8

0.0161

GO:0003008

System process

6 of 1127

1.03

0.74

0.0062

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031681

G-protein beta-subunit binding

5 of 26

2.59

4.36

4.38e-09

GO:0001664

G protein-coupled receptor binding

4 of 194

1.62

1.31

0.0013

GO:0048018

Receptor ligand activity

5 of 421

1.38

1.16

0.0013

GO:0005515

Protein binding

11 of 6815

0.52

0.41

0.0013

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005834

Heterotrimeric G-protein complex

5 of 50

2.31

3.68

4.27e-08

GO:0030141

Secretory granule

3 of 149

1.61

1.08

0.0051

GO:0030425

Dendrite

4 of 389

1.32

0.99

0.0035

GO:0043679

Axon terminus

2 of 50

1.91

0.85

0.0241

GO:0005886

Plasma membrane

8 of 5191

0.5

0.31

0.0462

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:21631

Mixed, incl. GTPase complex, and G protein-coupled amine receptor activity

7 of 147

1.99

3.86

9.47e-10

CL:22019

Galanin receptor activity, and Neuropeptide binding

4 of 15

2.73

3.83

7.03e-08

CL:21640

GTPase complex, and G protein-coupled amine receptor activity

6 of 115

2.03

3.51

1.53e-08

CL:21653

G beta:gamma signalling through BTK, and Amino terminal of the G-protein receptor rhodopsin

4 of 23

2.55

3.45

2.82e-07

CL:22023

Vertebrate endogenous opioids neuropeptide, and Neuropeptide binding

3 of 6

3.01

3.06

2.63e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04371

Apelin signaling pathway

5 of 208

1.69

2.15

6.51e-06

map04080

Neuroactive ligand-receptor interaction

6 of 706

1.24

1.34

4.05e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-202040

G-protein activation

8 of 38

2.63

8.11

4.57e-17

MAP-111885

Opioid Signalling

8 of 114

2.15

5.71

4.18e-14

MAP-418594

G alpha (i) signalling events

11 of 430

1.72

4.43

1.28e-16

MAP-392451

G beta:gamma signalling through PI3Kgamma

5 of 39

2.42

4.36

2.21e-09

MAP-381676

Glucagon-like Peptide-1 (GLP1) regulates insulin secretion

5 of 46

2.34

4.16

4.25e-09

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005834

Heterotrimeric G-protein complex

4 of 15

2.73

3.61

1.85e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0449

Lipoprotein

5 of 64

2.2

3.59

3.79e-08

KW-0807

Transducer

6 of 629

1.29

1.42

3.61e-05

KW-1003

Cell membrane

5 of 464

1.34

1.33

0.00019

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01160

Vertebrate endogenous opioids neuropeptide

2 of 3

3.13

1.28

0.0050

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00224

G protein gamma subunit-like motifs

5 of 22

2.66

4.83

6.16e-10

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