Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CALHM5Calcium homeostasis modulator family member 5. (309 aa)    
Predicted Functional Partners:
RTL6
Retrotransposon Gag like 6.
      
 0.497
C1orf109
Chromosome 1 open reading frame 109.
   
    0.465
G3TLL1_LOXAF
Uncharacterized protein.
   
    0.465
RUBCNL
Rubicon like autophagy enhancer.
   
    0.463
CWC25
CWC25 spliceosome associated protein homolog.
   
    0.462
SPATC1
Spermatogenesis and centriole associated 1.
      
 0.455
MOCS3
Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...]
   
    0.455
FBXO47
F-box protein 47.
   
    0.420
HAND1
Heart and neural crest derivatives expressed 1.
      
 0.418
VCL
Vinculin.
      
 0.416
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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