HDAC8 protein (Loxodonta africana) - STRING interaction network

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HDAC8

Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (377 aa)

Predicted Functional Partners:

MACROH2A1

0.918

MACROH2A2

0.906

RCOR1

0.892

H2AZ2

0.892

H2AZ1

0.892

RB1

0.874

KDM1A

0.849

HDAC3

0.844

ARID4A

0.839

ARID4B

0.839

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARID4A	ARID4B	ENSLAFP00000007267	ENSLAFP00000022187	AT-rich interaction domain 4A.	AT-rich interaction domain 4B.	0.963
ARID4A	H2AZ1	ENSLAFP00000007267	ENSLAFP00000018600	AT-rich interaction domain 4A.	Histone H2A; Belongs to the histone H2A family.	0.825
ARID4A	H2AZ2	ENSLAFP00000007267	ENSLAFP00000005184	AT-rich interaction domain 4A.	Histone H2A; Belongs to the histone H2A family.	0.825
ARID4A	HDAC3	ENSLAFP00000007267	ENSLAFP00000006680	AT-rich interaction domain 4A.	Hist_deacetyl domain-containing protein.	0.839
ARID4A	HDAC8	ENSLAFP00000007267	ENSLAFP00000007147	AT-rich interaction domain 4A.	Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.839
ARID4A	KDM1A	ENSLAFP00000007267	ENSLAFP00000006696	AT-rich interaction domain 4A.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.464
ARID4A	MACROH2A1	ENSLAFP00000007267	ENSLAFP00000006231	AT-rich interaction domain 4A.	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.	0.593
ARID4A	MACROH2A2	ENSLAFP00000007267	ENSLAFP00000019979	AT-rich interaction domain 4A.	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.	0.593
ARID4A	RB1	ENSLAFP00000007267	ENSLAFP00000028512	AT-rich interaction domain 4A.	RB transcriptional corepressor 1.	0.848
ARID4A	RCOR1	ENSLAFP00000007267	ENSLAFP00000004634	AT-rich interaction domain 4A.	REST corepressor 1.	0.474
ARID4B	ARID4A	ENSLAFP00000022187	ENSLAFP00000007267	AT-rich interaction domain 4B.	AT-rich interaction domain 4A.	0.963
ARID4B	H2AZ1	ENSLAFP00000022187	ENSLAFP00000018600	AT-rich interaction domain 4B.	Histone H2A; Belongs to the histone H2A family.	0.825
ARID4B	H2AZ2	ENSLAFP00000022187	ENSLAFP00000005184	AT-rich interaction domain 4B.	Histone H2A; Belongs to the histone H2A family.	0.825
ARID4B	HDAC3	ENSLAFP00000022187	ENSLAFP00000006680	AT-rich interaction domain 4B.	Hist_deacetyl domain-containing protein.	0.839
ARID4B	HDAC8	ENSLAFP00000022187	ENSLAFP00000007147	AT-rich interaction domain 4B.	Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.839
ARID4B	KDM1A	ENSLAFP00000022187	ENSLAFP00000006696	AT-rich interaction domain 4B.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.550
ARID4B	MACROH2A1	ENSLAFP00000022187	ENSLAFP00000006231	AT-rich interaction domain 4B.	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.	0.596
ARID4B	MACROH2A2	ENSLAFP00000022187	ENSLAFP00000019979	AT-rich interaction domain 4B.	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.	0.593
ARID4B	RB1	ENSLAFP00000022187	ENSLAFP00000028512	AT-rich interaction domain 4B.	RB transcriptional corepressor 1.	0.479
ARID4B	RCOR1	ENSLAFP00000022187	ENSLAFP00000004634	AT-rich interaction domain 4B.	REST corepressor 1.	0.560

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