Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
SERPINB2Serpin family B member 2; Belongs to the serpin family. (415 aa)    
Predicted Functional Partners:
PLAU
Plasminogen activator, urokinase.
    
 0.955
PLAT
Plasminogen activator; Belongs to the peptidase S1 family.
    
 0.941
SERPINE2
Serpin family E member 2; Belongs to the serpin family.
  
  
0.874
SERPINE1
Serpin family E member 1; Belongs to the serpin family.
  
  
0.848
DNPH1
2'-deoxynucleoside 5'-phosphate N-hydrolase 1; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.
      
 0.822
SERPINA4
Serpin family A member 4; Belongs to the serpin family.
  
0.794
SERPINA7
Serpin family A member 7; Belongs to the serpin family.
  
0.790
SERPINA5
Serpin family A member 5; Belongs to the serpin family.
  
0.783
PLAUR
Plasminogen activator, urokinase receptor.
   
 0.759
PLG
Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]
   
 0.745
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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