CYP11A1 protein (Loxodonta africana) - STRING interaction network

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CYP11A1

Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (518 aa)

Predicted Functional Partners:

HSD3B2

0.921

CYP17A1

0.915

HSD17B1

0.912

CYP21A2

0.903

CYP7B1

0.897

CYP19A1

0.897

HSD17B3

0.894

HSD11B2

0.874

SRD5A3

0.866

SRD5A1

0.851

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYP11A1	CYP17A1	ENSLAFP00000007182	ENSLAFP00000001709	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.	0.915
CYP11A1	CYP19A1	ENSLAFP00000007182	ENSLAFP00000029344	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	0.897
CYP11A1	CYP21A2	ENSLAFP00000007182	ENSLAFP00000021082	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 21 subfamily A member 2; Belongs to the cytochrome P450 family.	0.903
CYP11A1	CYP7B1	ENSLAFP00000007182	ENSLAFP00000010665	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family.	0.897
CYP11A1	HSD11B2	ENSLAFP00000007182	ENSLAFP00000007513	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Hydroxysteroid 11-beta dehydrogenase 2.	0.874
CYP11A1	HSD17B1	ENSLAFP00000007182	ENSLAFP00000008903	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Hydroxysteroid 17-beta dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.912
CYP11A1	HSD17B3	ENSLAFP00000007182	ENSLAFP00000011232	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.894
CYP11A1	HSD3B2	ENSLAFP00000007182	ENSLAFP00000027054	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family.	0.921
CYP11A1	SRD5A1	ENSLAFP00000007182	ENSLAFP00000010823	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	S5A_REDUCTASE domain-containing protein.	0.851
CYP11A1	SRD5A3	ENSLAFP00000007182	ENSLAFP00000019964	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Steroid 5 alpha-reductase 3.	0.866
CYP17A1	CYP11A1	ENSLAFP00000001709	ENSLAFP00000007182	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	0.915
CYP17A1	CYP19A1	ENSLAFP00000001709	ENSLAFP00000029344	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	0.943
CYP17A1	CYP21A2	ENSLAFP00000001709	ENSLAFP00000021082	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 21 subfamily A member 2; Belongs to the cytochrome P450 family.	0.902
CYP17A1	CYP7B1	ENSLAFP00000001709	ENSLAFP00000010665	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family.	0.904
CYP17A1	HSD11B2	ENSLAFP00000001709	ENSLAFP00000007513	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.	Hydroxysteroid 11-beta dehydrogenase 2.	0.944
CYP17A1	HSD17B1	ENSLAFP00000001709	ENSLAFP00000008903	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.	Hydroxysteroid 17-beta dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.944
CYP17A1	HSD17B3	ENSLAFP00000001709	ENSLAFP00000011232	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.	Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.959
CYP17A1	HSD3B2	ENSLAFP00000001709	ENSLAFP00000027054	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family.	0.972
CYP17A1	SRD5A1	ENSLAFP00000001709	ENSLAFP00000010823	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.	S5A_REDUCTASE domain-containing protein.	0.953
CYP17A1	SRD5A3	ENSLAFP00000001709	ENSLAFP00000019964	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.	Steroid 5 alpha-reductase 3.	0.886

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