Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AIREAutoimmune regulator. (557 aa)    
Predicted Functional Partners:
FOXN1
Forkhead box N1.
   
 0.840
FOXP3
Forkhead box P3.
    
 
 0.805
CREBBP
CREB binding protein.
   
 0.736
RBBP4
RB binding protein 4, chromatin remodeling factor.
   
 0.713
RBBP7
RB binding protein 7, chromatin remodeling factor.
   
 0.713
G3UII3_LOXAF
Uncharacterized protein.
      
 0.704
GATAD2B
GATA zinc finger domain containing 2B.
   
 0.701
KDM1A
Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.
   
 0.701
GATAD2A
GATA zinc finger domain containing 2A.
   
 0.701
MBD2
Methyl-CpG binding domain protein 2.
    
 0.693
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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