STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HBEGFHeparin binding EGF like growth factor. (208 aa)    
Predicted Functional Partners:
EGFR
Receptor protein-tyrosine kinase.
    
 0.994
ERBB4
GF_recep_IV domain-containing protein.
    
 0.983
MMP9
Matrix metallopeptidase 9.
   
 0.943
MMP2
Matrix metallopeptidase 2.
    
 0.929
MMP14
Matrix metallopeptidase 14.
   
 0.920
MMP16
Matrix metallopeptidase 16.
   
 0.918
MMP24
Matrix metallopeptidase 24.
   
 0.918
EGF
Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.
     
 0.856
ERBB2
Receptor protein-tyrosine kinase.
    
 0.822
BTC
Betacellulin.
     
0.739
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.