Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SMPDL3BAcid sphingomyelinase-like phosphodiesterase. (456 aa)    
Predicted Functional Partners:
SMPD2
Sphingomyelin phosphodiesterase 2.
     
 0.817
CERK
Ceramide kinase.
    
 0.795
ASAH2
Neutral ceramidase.
     
 0.788
UGCG
UDP-glucose ceramide glucosyltransferase.
     
 0.785
ASAH1
N-acylsphingosine amidohydrolase 1; Belongs to the acid ceramidase family.
   
 0.758
PLPP3
acidPPc domain-containing protein.
     
 0.723
G3TXD8_LOXAF
Uncharacterized protein.
     
 0.716
SAMD8
Sterile alpha motif domain containing 8.
     
 0.713
SMPD4
Sphingomyelin phosphodiesterase 4.
     
 0.713
ACER2
Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
     
 0.704
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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