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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (525 aa)    
Predicted Functional Partners:
SIX4
SIX homeobox 4.
   
 
 0.595
SIX1
SIX homeobox 1.
   
 
 0.548
G3UMV3_LOXAF
Homeobox domain-containing protein.
   
 
 0.548
SIX5
SIX homeobox 5.
   
 
 0.540
MRE11
Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
   
 
  0.531
ATM
Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]
     
 0.530
HSPB7
Heat shock protein family B (small) member 7; Belongs to the small heat shock protein (HSP20) family.
   
  
 0.522
TAC1
Tachykinin precursor 1.
      
 0.518
G3TBU1_LOXAF
Uncharacterized protein.
      
 0.515
EYA2
Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.
  
  
0.486
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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