C12orf66 protein (Loxodonta africana) - STRING interaction network

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C12orf66

Chromosome 12 open reading frame 66. (445 aa)

Predicted Functional Partners:

ITFG2

0.999

KPTN

0.997

WDR24

0.992

DEPDC5

0.983

WDR59

0.980

NPRL2

0.978

BMT2

0.943

NPRL3

0.875

PPP1R3A

0.849

G3SP06_LOXAF

0.834

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMT2	C12orf66	ENSLAFP00000022217	ENSLAFP00000007247	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Chromosome 12 open reading frame 66.	0.943
BMT2	DEPDC5	ENSLAFP00000022217	ENSLAFP00000010258	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	DEP domain-containing protein.	0.954
BMT2	ITFG2	ENSLAFP00000022217	ENSLAFP00000019241	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Integrin alpha FG-GAP repeat containing 2.	0.948
BMT2	KPTN	ENSLAFP00000022217	ENSLAFP00000007777	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Kaptin, actin binding protein.	0.924
BMT2	NPRL2	ENSLAFP00000022217	ENSLAFP00000001599	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	NPR2 like, GATOR1 complex subunit.	0.874
BMT2	NPRL3	ENSLAFP00000022217	ENSLAFP00000022568	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	NPR3 like, GATOR1 complex subunit.	0.866
BMT2	WDR59	ENSLAFP00000022217	ENSLAFP00000019664	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	WD repeat domain 59.	0.411
C12orf66	BMT2	ENSLAFP00000007247	ENSLAFP00000022217	Chromosome 12 open reading frame 66.	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	0.943
C12orf66	DEPDC5	ENSLAFP00000007247	ENSLAFP00000010258	Chromosome 12 open reading frame 66.	DEP domain-containing protein.	0.983
C12orf66	G3SP06_LOXAF	ENSLAFP00000007247	ENSLAFP00000001395	Chromosome 12 open reading frame 66.	Uncharacterized protein.	0.834
C12orf66	ITFG2	ENSLAFP00000007247	ENSLAFP00000019241	Chromosome 12 open reading frame 66.	Integrin alpha FG-GAP repeat containing 2.	0.999
C12orf66	KPTN	ENSLAFP00000007247	ENSLAFP00000007777	Chromosome 12 open reading frame 66.	Kaptin, actin binding protein.	0.997
C12orf66	NPRL2	ENSLAFP00000007247	ENSLAFP00000001599	Chromosome 12 open reading frame 66.	NPR2 like, GATOR1 complex subunit.	0.978
C12orf66	NPRL3	ENSLAFP00000007247	ENSLAFP00000022568	Chromosome 12 open reading frame 66.	NPR3 like, GATOR1 complex subunit.	0.875
C12orf66	PPP1R3A	ENSLAFP00000007247	ENSLAFP00000007757	Chromosome 12 open reading frame 66.	Protein phosphatase 1 regulatory subunit 3A.	0.849
C12orf66	WDR24	ENSLAFP00000007247	ENSLAFP00000012008	Chromosome 12 open reading frame 66.	WD repeat domain 24.	0.992
C12orf66	WDR59	ENSLAFP00000007247	ENSLAFP00000019664	Chromosome 12 open reading frame 66.	WD repeat domain 59.	0.980
DEPDC5	BMT2	ENSLAFP00000010258	ENSLAFP00000022217	DEP domain-containing protein.	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	0.954
DEPDC5	C12orf66	ENSLAFP00000010258	ENSLAFP00000007247	DEP domain-containing protein.	Chromosome 12 open reading frame 66.	0.983
DEPDC5	ITFG2	ENSLAFP00000010258	ENSLAFP00000019241	DEP domain-containing protein.	Integrin alpha FG-GAP repeat containing 2.	0.979

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