| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BMT2 | C12orf66 | ENSLAFP00000022217 | ENSLAFP00000007247 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Chromosome 12 open reading frame 66. | 0.906 |
| BMT2 | DEPDC5 | ENSLAFP00000022217 | ENSLAFP00000010258 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | DEP domain-containing protein. | 0.861 |
| BMT2 | ITFG2 | ENSLAFP00000022217 | ENSLAFP00000019241 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Integrin alpha FG-GAP repeat containing 2. | 0.878 |
| BMT2 | KPTN | ENSLAFP00000022217 | ENSLAFP00000007777 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Kaptin, actin binding protein. | 0.795 |
| BMT2 | MIOS | ENSLAFP00000022217 | ENSLAFP00000004259 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Meiosis regulator for oocyte development. | 0.416 |
| BMT2 | NPRL2 | ENSLAFP00000022217 | ENSLAFP00000001599 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | NPR2 like, GATOR1 complex subunit. | 0.824 |
| BMT2 | NPRL3 | ENSLAFP00000022217 | ENSLAFP00000022568 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | NPR3 like, GATOR1 complex subunit. | 0.791 |
| BMT2 | WDR24 | ENSLAFP00000022217 | ENSLAFP00000012008 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | WD repeat domain 24. | 0.441 |
| BMT2 | WDR59 | ENSLAFP00000022217 | ENSLAFP00000019664 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | WD repeat domain 59. | 0.440 |
| C12orf66 | BMT2 | ENSLAFP00000007247 | ENSLAFP00000022217 | Chromosome 12 open reading frame 66. | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | 0.906 |
| C12orf66 | DEPDC5 | ENSLAFP00000007247 | ENSLAFP00000010258 | Chromosome 12 open reading frame 66. | DEP domain-containing protein. | 0.973 |
| C12orf66 | ITFG2 | ENSLAFP00000007247 | ENSLAFP00000019241 | Chromosome 12 open reading frame 66. | Integrin alpha FG-GAP repeat containing 2. | 0.995 |
| C12orf66 | KPTN | ENSLAFP00000007247 | ENSLAFP00000007777 | Chromosome 12 open reading frame 66. | Kaptin, actin binding protein. | 0.993 |
| C12orf66 | MIOS | ENSLAFP00000007247 | ENSLAFP00000004259 | Chromosome 12 open reading frame 66. | Meiosis regulator for oocyte development. | 0.678 |
| C12orf66 | NPRL2 | ENSLAFP00000007247 | ENSLAFP00000001599 | Chromosome 12 open reading frame 66. | NPR2 like, GATOR1 complex subunit. | 0.966 |
| C12orf66 | NPRL3 | ENSLAFP00000007247 | ENSLAFP00000022568 | Chromosome 12 open reading frame 66. | NPR3 like, GATOR1 complex subunit. | 0.757 |
| C12orf66 | PPP1R3A | ENSLAFP00000007247 | ENSLAFP00000007757 | Chromosome 12 open reading frame 66. | Protein phosphatase 1 regulatory subunit 3A. | 0.691 |
| C12orf66 | WDR24 | ENSLAFP00000007247 | ENSLAFP00000012008 | Chromosome 12 open reading frame 66. | WD repeat domain 24. | 0.966 |
| C12orf66 | WDR59 | ENSLAFP00000007247 | ENSLAFP00000019664 | Chromosome 12 open reading frame 66. | WD repeat domain 59. | 0.968 |
| DEPDC5 | BMT2 | ENSLAFP00000010258 | ENSLAFP00000022217 | DEP domain-containing protein. | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | 0.861 |