Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PTCRAUncharacterized protein. (173 aa)    
Predicted Functional Partners:
RPL7L1
Ribosomal protein L7 like 1.
      
 0.814
POLR1B
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
      
 0.807
SLC5A2
Solute carrier family 5 member 2; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
      
 0.691
CD72
CD72 molecule.
      
 0.657
KIRREL3
Kirre like nephrin family adhesion molecule 3.
      
 0.556
GP1BA
Glycoprotein Ib platelet subunit alpha.
   
  
 0.497
TMEM145
Transmembrane protein 145.
      
 0.495
SLC25A1
Solute carrier family 25 member 1; Belongs to the mitochondrial carrier (TC 2.A.29) family.
      
 0.494
LAG3
Lymphocyte activating 3.
      
 0.476
TOP3B
DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.
      
 0.465
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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