Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
UIMC1Ubiquitin interaction motif containing 1. (714 aa)    
Predicted Functional Partners:
BRCC3
BRCA1/BRCA2-containing complex subunit 3.
    
 0.998
BABAM1
Uncharacterized protein.
    
 0.998
BABAM2
BRISC and BRCA1 A complex member 2.
    
 0.997
BRCA1
Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]
    
 0.991
BARD1
BRCA1 associated RING domain 1.
   
 0.974
PAXIP1
PAX interacting protein 1.
    
 0.868
MDC1
Mediator of DNA damage checkpoint 1.
    
 0.868
TP53BP1
Tumor protein p53 binding protein 1.
    
 0.845
UBA52
Ubiquitin A-52 residue ribosomal protein fusion product 1.
   
 0.821
RPS27A
Ubiquitin-like domain-containing protein.
    
 0.818
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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