Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
CD70TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (198 aa)    
Predicted Functional Partners:
CD27
CD27 molecule.
    
 0.994
TNFSF9
TNF superfamily member 9; Belongs to the tumor necrosis factor family.
   
  
 0.711
G3U4G1_LOXAF
Ig-like domain-containing protein.
      
 0.602
TNFRSF4
TNF receptor superfamily member 4.
   
  
 0.594
CD40LG
CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.
      
 0.594
CD22
CD22 molecule.
      
 0.559
CD38
Uncharacterized protein.
      
 0.556
TNFSF4
TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.
   
  
 0.520
CD40
CD40 molecule.
   
  
 0.506
TNFSF14
Tumor necrosis factor ligand 1D; Belongs to the tumor necrosis factor family.
      
 0.491
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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