STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CACHD1Cache domain containing 1. (1281 aa)    
Predicted Functional Partners:
SMPDL3B
Acid sphingomyelinase-like phosphodiesterase.
      
 0.645
CACNB3
Calcium voltage-gated channel auxiliary subunit beta 3.
   
 0.597
CACNB1
Calcium voltage-gated channel auxiliary subunit beta 1.
   
 0.597
CACNB2
Calcium voltage-gated channel auxiliary subunit beta 2.
   
 0.597
G3UMN1_LOXAF
SH3 domain-containing protein.
   
 0.597
EMC1
ER membrane protein complex subunit 1.
      
 0.584
STT3A
STT3 oligosaccharyltransferase complex catalytic subunit A.
    
 
 0.582
GGCX
Gamma-glutamyl carboxylase.
      
 0.578
CACNG1
Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.
    
 
 0.577
CACNA1E
Voltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents.
   
 0.460
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.