STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)    
Predicted Functional Partners:
CDK6
Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.
   
 0.999
CDK4
Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.
   
 0.998
CCND1
Cyclin D1; Belongs to the cyclin family.
    
 0.966
CCND2
Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.
    
 0.957
CCND3
Cyclin D3; Belongs to the cyclin family.
    
 0.957
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.915
CDK2
Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.
   
 0.682
CDK1
Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.
   
 0.659
CDK3
Cyclin dependent kinase 3; Belongs to the protein kinase superfamily.
   
 0.656
CDKN1A
Cyclin dependent kinase inhibitor 1A.
    
 0.614
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.