node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AHSA1 | SGTB | ENSLAFP00000004744 | ENSLAFP00000008653 | Activator of HSP90 ATPase activity 1. | Small glutamine rich tetratricopeptide repeat containing beta. | 0.582 |
GET3 | GET4 | ENSLAFP00000009801 | ENSLAFP00000013431 | ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | Guided entry of tail-anchored proteins factor 4. | 0.993 |
GET3 | NAA25 | ENSLAFP00000009801 | ENSLAFP00000011626 | ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | N(alpha)-acetyltransferase 25, NatB auxiliary subunit. | 0.530 |
GET3 | RAD23A | ENSLAFP00000009801 | ENSLAFP00000021367 | ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | RAD23 homolog A, nucleotide excision repair protein. | 0.832 |
GET3 | RAD23B | ENSLAFP00000009801 | ENSLAFP00000006334 | ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | RAD23 homolog B, nucleotide excision repair protein. | 0.829 |
GET3 | SEC61B | ENSLAFP00000009801 | ENSLAFP00000007202 | ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. | 0.687 |
GET3 | SGTB | ENSLAFP00000009801 | ENSLAFP00000008653 | ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | Small glutamine rich tetratricopeptide repeat containing beta. | 0.775 |
GET3 | STX5 | ENSLAFP00000009801 | ENSLAFP00000019690 | ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | Syntaxin 5; Belongs to the syntaxin family. | 0.811 |
GET4 | GET3 | ENSLAFP00000013431 | ENSLAFP00000009801 | Guided entry of tail-anchored proteins factor 4. | ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | 0.993 |
GET4 | RAD23A | ENSLAFP00000013431 | ENSLAFP00000021367 | Guided entry of tail-anchored proteins factor 4. | RAD23 homolog A, nucleotide excision repair protein. | 0.750 |
GET4 | RAD23B | ENSLAFP00000013431 | ENSLAFP00000006334 | Guided entry of tail-anchored proteins factor 4. | RAD23 homolog B, nucleotide excision repair protein. | 0.750 |
GET4 | SEC61B | ENSLAFP00000013431 | ENSLAFP00000007202 | Guided entry of tail-anchored proteins factor 4. | Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. | 0.613 |
GET4 | SGTB | ENSLAFP00000013431 | ENSLAFP00000008653 | Guided entry of tail-anchored proteins factor 4. | Small glutamine rich tetratricopeptide repeat containing beta. | 0.760 |
GET4 | STX5 | ENSLAFP00000013431 | ENSLAFP00000019690 | Guided entry of tail-anchored proteins factor 4. | Syntaxin 5; Belongs to the syntaxin family. | 0.405 |
LEO1 | RAD23A | ENSLAFP00000013731 | ENSLAFP00000021367 | LEO1 homolog, Paf1/RNA polymerase II complex component. | RAD23 homolog A, nucleotide excision repair protein. | 0.400 |
LEO1 | RAD23B | ENSLAFP00000013731 | ENSLAFP00000006334 | LEO1 homolog, Paf1/RNA polymerase II complex component. | RAD23 homolog B, nucleotide excision repair protein. | 0.400 |
LEO1 | SGTB | ENSLAFP00000013731 | ENSLAFP00000008653 | LEO1 homolog, Paf1/RNA polymerase II complex component. | Small glutamine rich tetratricopeptide repeat containing beta. | 0.777 |
LEO1 | TEP1 | ENSLAFP00000013731 | ENSLAFP00000002081 | LEO1 homolog, Paf1/RNA polymerase II complex component. | Telomerase associated protein 1. | 0.984 |
NAA25 | GET3 | ENSLAFP00000011626 | ENSLAFP00000009801 | N(alpha)-acetyltransferase 25, NatB auxiliary subunit. | ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | 0.530 |
NAA25 | SGTB | ENSLAFP00000011626 | ENSLAFP00000008653 | N(alpha)-acetyltransferase 25, NatB auxiliary subunit. | Small glutamine rich tetratricopeptide repeat containing beta. | 0.580 |