STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SERPINE1Serpin family E member 1; Belongs to the serpin family. (400 aa)    
Predicted Functional Partners:
PLAT
Plasminogen activator; Belongs to the peptidase S1 family.
   
 0.998
G3TMX5_LOXAF
SMB domain-containing protein.
   
 0.989
PLAU
Plasminogen activator, urokinase.
   
 0.986
SERPINB2
Serpin family B member 2; Belongs to the serpin family.
  
  
0.924
AGTR1
Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family.
    
 0.917
PLAUR
Plasminogen activator, urokinase receptor.
   
 0.863
PLG
Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]
    
 0.716
SLC2A4
Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
     
 0.674
CCL2
C-C motif chemokine.
   
 
 0.603
SERPINE2
Serpin family E member 2; Belongs to the serpin family.
  
  
 
0.589
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.