RAB21 protein (Loxodonta africana) - STRING interaction network

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Known Interactions

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Predicted Interactions

gene neighborhood

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Score

RAB21

RAB21, member RAS oncogene family. (222 aa)

Predicted Functional Partners:

RABGEF1

0.996

CHM

0.776

ANKRD27

0.772

GAPVD1

0.723

RABGGTB

0.649

GDI1

0.646

GDI2

0.646

G3TM43_LOXAF

0.576

SBF2

0.569

SBF1

0.569

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD27	CHM	ENSLAFP00000011663	ENSLAFP00000000437	Ankyrin repeat domain 27.	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	0.406
ANKRD27	GDI1	ENSLAFP00000011663	ENSLAFP00000007358	Ankyrin repeat domain 27.	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.	0.459
ANKRD27	GDI2	ENSLAFP00000011663	ENSLAFP00000007550	Ankyrin repeat domain 27.	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.	0.459
ANKRD27	RAB21	ENSLAFP00000011663	ENSLAFP00000010679	Ankyrin repeat domain 27.	RAB21, member RAS oncogene family.	0.772
CHM	ANKRD27	ENSLAFP00000000437	ENSLAFP00000011663	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	Ankyrin repeat domain 27.	0.406
CHM	G3TM43_LOXAF	ENSLAFP00000000437	ENSLAFP00000016125	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	Uncharacterized protein.	0.501
CHM	GAPVD1	ENSLAFP00000000437	ENSLAFP00000014212	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	GTPase activating protein and VPS9 domains 1.	0.457
CHM	GDI1	ENSLAFP00000000437	ENSLAFP00000007358	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.	0.543
CHM	GDI2	ENSLAFP00000000437	ENSLAFP00000007550	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.	0.543
CHM	RAB21	ENSLAFP00000000437	ENSLAFP00000010679	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	RAB21, member RAS oncogene family.	0.776
CHM	RABGEF1	ENSLAFP00000000437	ENSLAFP00000005889	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	Uncharacterized protein.	0.957
CHM	RABGGTB	ENSLAFP00000000437	ENSLAFP00000002585	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C- terminal sequence -XXCC, -XCXC and -CCXX.	0.962
CHM	SBF1	ENSLAFP00000000437	ENSLAFP00000027614	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	SET binding factor 1.	0.427
CHM	SBF2	ENSLAFP00000000437	ENSLAFP00000025681	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	SET binding factor 2.	0.427
G3TM43_LOXAF	CHM	ENSLAFP00000016125	ENSLAFP00000000437	Uncharacterized protein.	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	0.501
G3TM43_LOXAF	GDI1	ENSLAFP00000016125	ENSLAFP00000007358	Uncharacterized protein.	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.	0.424
G3TM43_LOXAF	GDI2	ENSLAFP00000016125	ENSLAFP00000007550	Uncharacterized protein.	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.	0.424
G3TM43_LOXAF	RAB21	ENSLAFP00000016125	ENSLAFP00000010679	Uncharacterized protein.	RAB21, member RAS oncogene family.	0.576
GAPVD1	CHM	ENSLAFP00000014212	ENSLAFP00000000437	GTPase activating protein and VPS9 domains 1.	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	0.457
GAPVD1	GDI1	ENSLAFP00000014212	ENSLAFP00000007358	GTPase activating protein and VPS9 domains 1.	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.	0.478

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Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.833

expected number of edges:

10

PPI enrichment p-value:

8.16e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009073

Aromatic amino acid family biosynthetic process

7 of 15

2.3

5.28

6.31e-12

GO:0046417

Chorismate metabolic process

4 of 6

2.46

3.07

1.32e-06

GO:0009423

Chorismate biosynthetic process

3 of 5

2.41

2.27

5.21e-05

GO:0009095

Aromatic amino acid family biosynthetic process, prephenate pathway

2 of 2

2.63

1.51

0.0017

GO:0008652

Cellular amino acid biosynthetic process

5 of 108

1.3

1.27

0.00023

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016838

Carbon-oxygen lyase activity, acting on phosphates

3 of 6

2.33

1.74

0.00054

GO:0003856

3-dehydroquinate synthase activity

2 of 2

2.63

1.26

0.0051

GO:0016835

Carbon-oxygen lyase activity

4 of 52

1.52

1.2

0.0019

GO:0016829

Lyase activity

5 of 130

1.22

0.99

0.0019

GO:0003824

Catalytic activity

11 of 2283

0.32

0.24

0.0462

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1157

Aromatic amino acid family biosynthetic process, and Anthranilate synthase component I-like

9 of 19

2.31

7.07

1.22e-16

CL:1159

Chorismate biosynthetic process

4 of 6

2.46

3.31

4.40e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

zga00400

Phenylalanine, tyrosine and tryptophan biosynthesis

10 of 23

2.27

8.0

6.95e-20

zga01230

Biosynthesis of amino acids

10 of 125

1.54

3.22

1.45e-13

zga01110

Biosynthesis of secondary metabolites

11 of 326

1.16

1.77

7.18e-12

zga01100

Metabolic pathways

11 of 716

0.82

0.89

2.77e-08

zga02024

Quorum sensing

2 of 26

1.52

0.69

0.0386

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005737

Cytoplasm

9 of 1110

0.54

0.36

0.0243

GOCC:0005622

Intracellular

10 of 1523

0.45

0.31

0.0243

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0057

Aromatic amino acid biosynthesis

3 of 11

2.07

1.76

0.00034

KW-0456

Lyase

6 of 116

1.35

1.54

2.15e-05

KW-0170

Cobalt

2 of 4

2.33

1.25

0.0049

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00425

Chorismate binding enzyme

2 of 3

2.46

0.82

0.0315

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR030963

3-dehydroquinate synthase family

2 of 2

2.63

0.74

0.0466

IPR030960

3-dehydroquinate synthase domain

2 of 2

2.63

0.74

0.0466

IPR015890

Chorismate-utilising enzyme, C-terminal

2 of 3

2.46

0.73

0.0466

IPR005801

ADC synthase

2 of 3

2.46

0.73

0.0466

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