STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MMP8Matrix metallopeptidase 8. (468 aa)    
Predicted Functional Partners:
TIMP1
TIMP metallopeptidase inhibitor 1.
   
 0.749
TIMP2
TIMP metallopeptidase inhibitor 2.
   
 0.717
ELANE
Elastase, neutrophil expressed; Belongs to the peptidase S1 family.
   
 0.687
TIMP3
TIMP metallopeptidase inhibitor 3.
   
 0.625
TIMP4
TIMP metallopeptidase inhibitor 4.
    
 0.609
SERPINH1
Serpin family H member 1; Belongs to the serpin family.
   
 0.558
MMP7
Matrix metallopeptidase 7.
  
0.548
MMP9
Matrix metallopeptidase 9.
   
0.515
PLG
Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]
   
 0.514
CDK9
Cyclin dependent kinase 9; Belongs to the protein kinase superfamily.
      
 0.509
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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