STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BRCC3BRCA1/BRCA2-containing complex subunit 3. (292 aa)    
Predicted Functional Partners:
BABAM2
BRISC and BRCA1 A complex member 2.
    
 0.998
BABAM1
Uncharacterized protein.
   
 0.998
ABRAXAS2
Abraxas 2, BRISC complex subunit.
    
 0.995
UIMC1
Ubiquitin interaction motif containing 1.
    
 0.993
UBXN7
UBX domain-containing protein 7.
   
 0.953
PSMD6
Proteasome 26S subunit, non-ATPase 6.
   
 0.951
BRCA1
Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]
    
 0.951
PSMC3
Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family.
  
 0.935
PSMD13
Proteasome 26S subunit, non-ATPase 13.
   
 0.933
PSMC2
Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family.
   
 0.933
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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