STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APCAPC regulator of WNT signaling pathway. (2836 aa)    
Predicted Functional Partners:
CTNNB1
Catenin beta 1.
   
 0.999
AXIN1
Axin 1.
   
 0.993
ARHGEF4
Rho guanine nucleotide exchange factor 4.
   
 0.992
GSK3B
Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.
    
 0.981
AMER1
APC membrane recruitment protein 1.
    
 0.957
LEF1
Lymphoid enhancer binding factor 1.
    
 0.949
TCF7
Transcription factor 7.
    
 0.949
DVL3
Dishevelled segment polarity protein 3.
    
 0.946
DVL2
Dishevelled segment polarity protein 2.
    
 0.946
SPATA13
Uncharacterized protein.
   
 0.943
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.