STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ANKRD9Ankyrin repeat domain 9. (317 aa)    
Predicted Functional Partners:
DNAJC17
DnaJ heat shock protein family (Hsp40) member C17.
   
  
 0.728
IBTK
Inhibitor of Bruton tyrosine kinase.
   
 0.726
CUL5
Cullin 5; Belongs to the cullin family.
    
 0.703
ELOC
Skp1_POZ domain-containing protein; Belongs to the SKP1 family.
    
 0.701
RNF7
Ring finger protein 7.
    
 0.697
KCTD9
Potassium channel tetramerization domain containing 9.
      
 0.644
ELOB
Elongin B.
    
 0.631
IMPDH2
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
    
 0.629
COMMD8
COMM domain containing 8.
   
  0.552
NEDD8
NEDD8 ubiquitin like modifier.
    
  0.545
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.