STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CRKLCRK like proto-oncogene, adaptor protein. (200 aa)    
Predicted Functional Partners:
CBL
Cbl proto-oncogene.
    
 0.997
BCAR1
BCAR1 scaffold protein, Cas family member.
    
 0.985
RAPGEF1
Rap guanine nucleotide exchange factor 1.
    
 0.980
GAB1
GRB2 associated binding protein 1.
    
 0.979
FRS2
Fibroblast growth factor receptor substrate 2.
   
 0.974
DOCK1
Dedicator of cytokinesis 1; Belongs to the DOCK family.
    
 0.973
EGFR
Receptor protein-tyrosine kinase.
    
 0.966
PXN
Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family.
    
 0.965
ABL1
Tyrosine-protein kinase.
    
 0.964
KIDINS220
Kinase D interacting substrate 220.
    
 0.960
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.